“No drug is perfect, as all drugs have side effects. “The elevation in cytochrome P450 could mean that other drugs taken with ibuprofen could stay in the body for a longer duration in males and this has never been shown before,” Gomes says. Ibuprofen elevated activity of cytochrome P450, which breaks down drugs, in females but decreased it in males. ![]() The researchers found that ibuprofen had different, and in some cases opposite, effects in the livers of male and female mice.įor example, the proteasome-a waste-disposal system that removes unwanted proteins-responded differently in males and females. Hydrogen peroxide damages proteins and stresses liver cells. They included pathways involved in metabolism of amino acids, hormones, and vitamins as well as production of reactive oxygen and hydrogen peroxide inside cells. ![]() “We found that ibuprofen caused many more protein expression changes in the liver than we expected,” Gomes says.Īt least 34 different metabolic pathways were altered in male mice treated with ibuprofen. Then they used advanced mass spectrometry to capture information on all the metabolic pathways in liver cells. Researchers dosed mice with a moderate amount of ibuprofen for a week-equivalent to an adult human taking about 400 mg of the drug daily. Ibuprofen belongs to a group of drugs called nonsteroidal anti-inflammatory drugs, or NSAIDs, widely used over the counter to treat pain and fever.Įxperts know that ibuprofen can cause heart problems and increase stroke risk, but the effects on the liver were less well understood, says Aldrin Gomes, professor in the neurobiology department at the University of California, Davis. The effects are markedly different in males and females, according to the study, which appears in Scientific Reports. ![]() The painkiller ibuprofen may have more significant effects on the liver than previously thought, a new study with mice shows. University University of California, Davis
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